Research Paper Volume 12, Issue 9 pp 7985—8000

PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway

Figure 7. The effects of PHLDA2 on autophagy and EMT are partially dependent upon the PI3K/AKT signaling pathway in CRC cells. (A, B) Levels of PI3K, AKT, p-AKTS473, mTOR, p-mTOR, and GSK3β proteins were assessed in stably-transfected HCT116 and SW480 cells. Data are shown as mean ± SD; ns: no statistically significant difference; *P < 0.05, **P < 0.01.