Research Paper Volume 12, Issue 9 pp 8016—8028

Honokiol inhibits carotid artery atherosclerotic plaque formation by suppressing inflammation and oxidative stress

Figure 2. Effect of honokiol on inflammatory response and oxidative stress in the carotid tissue of atherosclerotic mice. (AC) The mRNA expression of TNF-α (A), IL-6 (B), and IL-1β (C) in carotid tissue was detected by real-time PCR. (n = 6; * P < 0.05, ** P < 0.01, *** P < 0.001, vs. the ND group. # P < 0.05, ## P < 0.01, ### P < 0.001, vs. the WD group; one-way ANOVA). (D, E) The ROS level (D) and SOD activity (E) in carotid tissue were detected by commercial kits in the indicated group. (n = 6; * P < 0.05, ** P < 0.01, *** P < 0.001, vs. the ND group. # P < 0.05, ## P < 0.01, ### P < 0.001, vs. the WD group; one-way ANOVA). TNF-α: Tumor necrosis factor-α; interleukin-6: IL-6; and interleukin-1β: IL-1β; ND: normal diet; WD: Western-type diet; ROS: reactive oxygen species; SOD: superoxide dismutase.