Research Paper Volume 12, Issue 9 pp 8029—8048

Artesunate promotes the proliferation of neural stem/progenitor cells and alleviates Ischemia-reperfusion Injury through PI3K/Akt/FOXO-3a/p27kip1 signaling pathway

Figure 5. Systemic administration of ART reduced motor function impairment of MCAO animals in vivo. (A) The flow chart of experimental design. (B, C) The open field test was performed to measure general motor functions, and total travel distance and total travel speed were recorded. (D) Neurological evaluation (18-point scale assessment for the severity of impairment) was carried out to determine somatosensory movement function. (E) The ladder rung walking task was performed to evaluate fine motor function, and the slip ratio of the contralateral limbs was counted within 50 steps. Data are shown as the mean ± SEM, *p<0.05, **p<0.01, *** p<0.001 of MCAO+ART 150mg/kg vs. MCAO+Veh group; #p <0.05, ##p<0.01, ###p<0.001 of MCAO+ART 250mg/kg vs. MCAO+Veh group; @p<0.05, of MCAO+Veh group vs. sham group.