Research Paper Volume 12, Issue 9 pp 8029—8048

Artesunate promotes the proliferation of neural stem/progenitor cells and alleviates Ischemia-reperfusion Injury through PI3K/Akt/FOXO-3a/p27kip1 signaling pathway

Figure 7. Schematic summary. ART is able to promote the proliferation of NSPCs after ischemic injury both in vivo and in vitro, through the AKT/FOXO-3a/p27Kip1 pathway, thus improve the ischemic penumbra and reduce infarct volume, further promoting functional reconstruction.