Research Paper Volume 12, Issue 9 pp 8049—8066

Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice

Figure 2. Recombinant GDF11 treatment improved early neurological recovery by reducing brain inflammation after transient ischemic stroke. (A) a decrease in NDS at day 10 post MCAo, (B) pSmad2 and (C) psmad3 expression in the vehicle and rGDF11 treated mice at day 10 post-stroke, (D) decrease in brain IL-18 and (E) IL-15 levels in the MCAorGDF11 treated mice at day 10 post-stroke n=3-7,*p<0.05.