Research Paper Volume 12, Issue 10 pp 8953—8967

Valproic acid-labeled chitosan nanoparticles promote recovery of neuronal injury after spinal cord injury

Figure 3. VA-CN administration promoted recovery after SCI. (A) Basso, Beattie and Bresnahan (BBB) scores were evaluated at different time points after injury in Sham rats (n=9), SCI rats (n=10), CN treated rats (n=10), VA treated rats (n=12), and VA-CN treated rats (n=11). Six rats with perineal infections, limb wounds, or tail and foot grazing were eliminated from the test. * p<0.05 VS SCI group, # p<0.001 VS Sham group. (B, C) Void frequency and average void volume were tested at 4 weeks after SCI. n=6 per group, * p<0.05, ** p<0.01, *** p<0.001. (D) Residual urine volumes were recorded at different time points after injury. n=10 for Sham group, n=12 per experiment group, * p<0.05, ** p<0.01 VS SCI group. (E) The HE staining was performed at 4 weeks after injury (Scale bar: 100 μm). (F) The lesion cavity area was quantified in the injured spinal cords. n=10 for Sham group, n=12 per experiment group, * p<0.05, ** p<0.01 VS SCI group.