Research Paper Volume 12, Issue 9 pp 8107—8119

Nur77 attenuates inflammatory responses and oxidative stress by inhibiting phosphorylated IκB-α in Parkinson’s disease cell model

Figure 2. Effects of Nur77 on cytokines expression in MPP+-treated PC12 cells. (A) Nur77 increase NF-κB, TNF-α, IL-6 and MCP-1. (BE) CSN-B and siNur77 treatment alone did not effect expression of NF-κB, TNF-α, IL-6 and MCP-1. MPP+ incubation pronouncedly increased level of NF-κB, TNF-α, IL-6 and MCP-1, while this elevation was abolished by CSN-B. (***P < 0.001,**P < 0.01 compared with control group; $$P < 0.01, $P < 0.05, NS = not significant. compared with MMP+ group; n=3, mean +/- SEM).