Research Paper Volume 12, Issue 9 pp 8120—8136

Neuropeptide Y1 receptor antagonist promotes osteoporosis and microdamage repair and enhances osteogenic differentiation of bone marrow stem cells via cAMP/PKA/CREB pathway

Figure 1. OP group showed deteriorated bone microstructure and more microdamage than OA. (A) The position of the samples for micro-CT and microdamage analysis within the femoral head. (B) Representative micro-CT images of tibias, and comparison of the microstructure parameters between two groups. (C) Fluorescent images and comparison of microdamage (white arrow head) in the OA group and OP group (x 200). The data are expressed as the means ± SD (n = 10 in each group). *P<0.05; ***P<0.001; ****P<0.0001 vs. SHAM by the unpaired two-tailed Student’s t-test.