Research Paper Volume 12, Issue 9 pp 8120—8136

Neuropeptide Y1 receptor antagonist promotes osteoporosis and microdamage repair and enhances osteogenic differentiation of bone marrow stem cells via cAMP/PKA/CREB pathway

Figure 3. Y1R antagonist treatment improved bone microstructure and decrease microdamage in OVX rats. Representative micro-CT images of rat tibias (A) and quantitative analysis of bone microstructure (B). (C) In vivo fatigue loading model and the position of the sample for microdamage analysis in the rat tibia. Fluorescent images (D) and comparison (E) of microdamage (white arrow head) among groups (x 200). The data are expressed as the means ± SD (n = 6 in each group). *P<0.05; ***P<0.001; ****P<0.0001 vs. SHAM, and ##P<0.01; ####P<0.0001 vs. OVX by one-way ANOVA and Tukey’s post hoc test.