Research Paper Volume 12, Issue 9 pp 8151—8166

Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signaling pathway

Figure 5. Salidroside’s effect on hemostasis and arterial thrombosis in mice. Mice were injected with salidroside (20mg/kg) intraperitoneally followed by analysis of platelet count (A) (mean ± SE, n = 7) and tail bleeding time (mean ± SE, n = 6) (B). Salidroside (20 μM) or vehicle-treated platelets were labelled with calcein and infused into salidroside-treated or vehicle-treated mice respectively followed by challenging with 10% FeCl3 to induce arterial thrombus formation. The vessel occlusion time was recorded (mean ± SE, n = 6) (C). Data were analyzed by unpaired student t-test. *P < 0.05; **P < 0.01.