Research Paper Volume 12, Issue 9 pp 8151—8166

Salidroside inhibits platelet function and thrombus formation through AKT/GSK3β signaling pathway

Figure 8. Effect of inhibition of GSK3β on platelet function. Washed human (A and B) or mouse (C and D) platelets were pretreated with GSK3β inhibitor SB216763 (10 μM) for 2 h at 37C followed by treated with salidroside (20 μM) at 37 for 1 h. After that, platelet aggregation in response to thrombin (A and C) and clot retraction (B and D) was performed. The clot image was captured at 60 min after initiation. Data were shown as mean ± SE (n = 4) and analyzed by one-way ANOVA. *P < 0.05; **P < 0.01; ***P < 0.001. ns: not significant.