Research Paper Volume 12, Issue 9 pp 8167—8190

Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation

Figure 2. Inhibitory effects of lycopene on TPA-induced transformation of JB6 P+ cells in vitro. (A) Soft agar assay of cells with indicated treatment and time. Images were taken and analyzed using the ZEN pro 2012 imaging software on a Zeiss invert microscope under 100-fold magnification. (B) Quantitative analysis of the soft agar assay (n=3). The data are presented as the mean ± SD. ***p < 0.001 (versus TPA alone).