Research Paper Volume 12, Issue 9 pp 8191—8201

The shared KEGG pathways between icariin-targeted genes and osteoporosis

Figure 5. Icariin-targeted genes related to the top 5 shared KEGG pathways. (A) Icariin-targeted genes related to Toll-like receptor pro-inflammatory signaling: (1) PI3K-Akt signaling, (2) NF-kB, and (3) MAPK signaling pathway. (B) Icariin-targeted genes related to Adipocytokine signaling, and insulin resistance. (C) Icariin-targeted genes related to Neurotrophin signaling regulating cell survival and apoptosis. (4) JNK signaling pathway is involved in the process. (D) Icariin-targeted genes related to NOD-like receptor signaling pathway. (2) NF-kB, and (3) MAPK signaling pro-inflammatory pathways are involved. (E) Icariin-targeted genes related to B cell receptor signaling. (2) NF-kB pathway is involved, regulating B cell ontogeny, autoimmunity anergy, and immune responses.