Research Paper Volume 12, Issue 9 pp 8241—8260

Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a

Figure 7. Exosomal lncRNA-MALAT1/miR-92a-3p activated ATG4a to cause rejuvenation. (A) Cell cycle distribution was analyzed. (B and C) p53 and p21 mRNA levels were analyzed by qRT-PCR. (D) Percentage of β-gal-positive cells. (E) Representative images of SA-β -gal staining. Each column represents the mean ± SD of three independent experiments. *P < 0.05 versus control; P<0.05 versus Dox; P < 0.05 versus Dox + exosomeHypoxia + siRNA-ATG4a.