Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a

Wenzheng Xia; Hanbin Chen; Congying Xie; Meng Hou

doi:doi:10.18632/aging.103136

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Research Paper Volume 12, Issue 9 pp 8241—8260

Long-noncoding RNA MALAT1 sponges microRNA-92a-3p to inhibit doxorubicin-induced cardiac senescence by targeting ATG4a

Figure 8. Exosome^Hypoxia modified the metabolism of cardiomyocytes disturbed by Dox. (A) mRNA level of Fabp3, (B) mRNA level of Fabp4, (C) mRNA level of Mtfp1, (D) mRNA level of Cox4i2, (E) mRNA level of Hspa1a, and (F) mRNA level of Atp1b2. ^*P < 0.05 versus Control; ^▲P < 0.05 versus Dox; °P < 0.05 versus Dox + exosome^{Hypoxia+siRNA-LncRNA-MALAT1}; ^□P < 0.05 versus Dox + exosome^Hypoxia + miR-92a-3p mimic; ^●P < 0.05 versus Dox + exosome^Hypoxia +siRNA-ATG4a.