Research Paper Volume 12, Issue 9 pp 8261—8288

Identification of candidate lncRNAs and circRNAs regulating WNT3/β-catenin signaling in essential hypertension

Figure 2. Co-expression subnetwork of DE lncRNAs associated with WNT3 and CAMK2N2. (A) Co-expression network analysis indicating positive correlation between 7 DE lncRNAs and both WNT3 and CAMK2N2. (B) A positive correlation with both WNT3 and CAMK2N2 was detected for 14 circRNAs. We used the circBase database for gene annotation; only one gene was not annotated in circBase. (C, D) A miRNA-based sponge regulatory subnetwork depicting LOC646616/miRNA/WNT3 and LOC646616/miRNA/CAMK2N2 interactive modules.