Research Paper Volume 12, Issue 9 pp 8301—8320

Long non-coding RNA CCAT1 promotes colorectal cancer progression by regulating miR-181a-5p expression

Figure 8. LncRNA CCAT1 knockdown impaired colorectal cancer cell tumor growth in vivo. (AC) The in vivo tumor formation assay suggested that CCAT1 knockdown dramatically reduced tumor size and weight in 5 samples of each group. (D) The expression of CCAT1 was downregulated in resected tumor tissues formed from CCAT1 knockdown. (E, F) Immunohistochemistry showed CCAT1 knockdown decreased the proliferation index Ki67 (×50). *P<0.05, **P<0.01, ***P<0.001, compared with NC group.