Research Paper Volume 12, Issue 21 pp 21076—21090

Downregulation of interleukin-6 and C-reactive protein underlies a novel inhibitory role of microRNA-136-5p in acute lower extremity deep vein thrombosis

Figure 1. miR-136-5p is downregulated, but IL-6 and CRP are upregulated in DVT patients. (A) The expression levels of miR-136-5p, IL-6, and CRP in patients with (n = 55) and without DVT (n = 74) detected by RT-qPCR. (B) The protein expression levels of miR-136-5p, IL-6, and CRP in patients with (n = 55) and without DVT (n = 74) detected by ELISA. (C) The association between miR-136-5p expression and IL-6 mRNA expression analyzed by Pearson’s correlation analysis. (D) The association between miR-136-5p expression and CRP mRNA expression analyzed by Pearson’s correlation analysis. ** p < 0.01 compared with the patients without DVT. Measurement data were expressed as mean ± standard deviation. Data from two groups were compared using independent sample t-test. miR-136-5p, microRNA-136-5p; IL-6, interleukin-6; CRP, C-reactive protein; DVT, deep vein thrombosis; RT-qPCR, reverse transcription quantitative polymerase chain reaction; ELISA, enzyme linked immunosorbent assay.