Research Paper Volume 12, Issue 21 pp 21076—21090

Downregulation of interleukin-6 and C-reactive protein underlies a novel inhibitory role of microRNA-136-5p in acute lower extremity deep vein thrombosis

Figure 6. A schematic diagram depicting the regulatory mechanism of miR-136-5p acting through IL-6 and CRP in acute LEDVT. Overexpression of miR-136-5p targeted IL-6 and CRP to block the coagulation cascade and consequent endothelial injury, thus inhibiting venous thrombus formation and ultimately alleviating acute LEDVT. miR-136-5p, microRNA-136-5p; IL-6, interleukin-6; CRP, C-reactive protein; LEDVT, lower extremity deep vein thrombosis.