Research Paper Volume 12, Issue 9 pp 8352—8371

Exosomal miR-183-5p promotes angiogenesis in colorectal cancer by regulation of FOXO1

Figure 5. Inhibition of miR-183-5p in HT29 cells reduces the tumorigenic ability and decreases the MVD in nude mice. (A) tumorigenicity of HT29 cells in nude mice; (B and C) tumor volume and weight from nude mice; (D) serum level of VEGFA detected by ELISA; (E, F) immunohistochemical analysis (Scale bar = 25 μm) and quantitation of MVD in nude mice; *p < 0.05 compared with the HT29-NC group; Measurement data were presented as mean ± standard deviation; comparisons between two groups were conducted by means of independent t-test, n = 10.