Research Paper Volume 12, Issue 9 pp 8372—8396

KIF23 activated Wnt/β-catenin signaling pathway through direct interaction with Amer1 in gastric cancer

Figure 7. Schematic figure represented the functions of KIF23 in the Wnt/β-catenin signaling pathway in GC. The KIF23 overexpression exhibited competitive binding with Amer1 and carried it to the nuclear to block the association of Amer1 with APC, thus attenuating the ability of Amer1 to negatively regulate Wnt/β-catenin signaling, resulting in activation of this signaling pathway.