Research Paper Volume 12, Issue 9 pp 8549—8564

Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells in vitro and in vivo

Figure 7. Exosomal miRNA-34 inhibits tumor growth of GC cells in vivo. (A) Exosomes derived from GCFs labeled with Cre could be taken up by GC cells of tumor tissue. Scale bars: 50 μm. (B) The expression of miRNA-34 in exosomes transfected with miRNA-34 mimics. (C) Representative image of excised xenograft tumors. (D) Tumor growth curve. (E) The expression of miRNA-34 in tumor tissues treated with exosomes loaded with miRNA-34 mimics.