Research Paper Volume 12, Issue 13 pp 12726—12739

EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

Figure 8. EZH2 knockout inhibits HF keratinocyte differentiation and hair growth, but facilitated apoptosis in vivo. (A) Hair loss exhibited by EZH2-/- mice of 30 days old. (B) Delayed hair growth ability in EZH2-/- mice. (C) HF in EZH2-/- mice and WT mice determined by ALP staining. (D) Expression of proliferation, differentiation, and apoptosis markers EZH2-/- mice and WT mice detected by immunofluorescence assay (400 ×). * p < 0.05 vs. WT mice; Measurement data were expressed as mean ± standard deviation. Unpaired t test was adopted to analyze the differences between two experimental groups if the data conformed to normal distribution and homogeneity of variance. n = 15.