Research Paper Volume 12, Issue 13 pp 12726—12739

EZH2-mediated inhibition of microRNA-22 promotes differentiation of hair follicle stem cells by elevating STK40 expression

Figure 9. Schematic diagram representing the role of the EZH2/miR-22/STK40/MEF2-ALP axis in HFSC proliferation and differentiation. EZH2 inhibits miR-22 expression by accelerating H3K27me3 methylation, which in turn upregulates STK40, thereby accelerating proliferation and differentiation of HFSCs by activating MEF2-ALP activity.