Research Paper Volume 12, Issue 10 pp 9041—9065

Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis

Figure 1. Sigma-1 Receptor Expression in Ovary Tissue. Ovarian cortex in women of childbearing age (A, ×200) (C, ×400) showed intense immunostaining. Intense immunostaining was observed inovarian granulosa cells and theca cells of growing follicle (B, ×400). Granulosa cells of mature follicle also showed intense staining (D, ×200). Low immunostaining was observed in human ovarian stromal cells (E, ×400).