Research Paper Volume 12, Issue 10 pp 9041—9065

Sigma-1 receptor is involved in diminished ovarian reserve possibly by influencing endoplasmic reticulum stress-mediated granulosa cells apoptosis

Figure 5. KGN cells treated with DHEA- and sigma-1 receptor ligands revealed similar biological effects to SIGMAR1-overexpressed cells and opposite effects to SIGMAR1-knockdown KGN cells. (A) Sigma-1 receptor mRNA levels in differently treated KGN cells. SIGMAR1-overexpressed and SIGMAR1-knockdown KGN cells were constructed successfully. (B) The mRNA levels of ERS and apoptosis-related genes in differently treated KGN cells. *P<0.05.