Research Paper Volume 12, Issue 10 pp 9066—9084

Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway

Figure 5. miR-142-5p reduced liver injury, liver fatty degeneration and liver fibrosis, which could be rescued by JAK-STAT signaling pathway activator or AAV/TSLP. (A) The level of alanine aminotransferase (ALT) secreted into serum. (B) The level of aspartate aminotransferase (AST) secreted into serum. (C, E) H&E staining for liver fatty degeneration. Original magnification ×200. (D, F) The representative images of collagen deposition in Masson’s trichrome. The expression of fibrosis-related genes. Original magnification ×200. (G) The mRNA expression level of Tgfβ and (H) The mRNA expression level of Collagen-1 α2. *P < 0.05, compared with WT group; #P < 0.05, compared with NC group; ^P < 0.05, compared with A142 group. All data were means ± SD.