Research Paper Volume 12, Issue 10 pp 9066—9084

Overexpression of miR-142-5p inhibits the progression of nonalcoholic steatohepatitis by targeting TSLP and inhibiting JAK-STAT signaling pathway

Figure 8. Knockdown TSLP reduced liver injury, liver fatty degeneration and liver fibrosis, which could be rescued by JAK-STAT signaling pathway activator. (A) The level of alanine aminotransferase (ALT) secreted into serum. (B) The level of aspartate aminotransferase (AST) secreted into serum. (C) Liver fatty degeneration was detected by H&E staining; (D) The degree of fibrosis was shown by Masson’s trichrome Original magnification ×200. (E) The mRNA expression level of Tgfβ and (F) The mRNA expression level of Collagen-1α2. *P < 0.05, compared with WT group; #P < 0.05, compared with NC group; &P < 0.05, compared with sh-TSLP group. All data were mean ± SD.