lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis

Yanni Yang; Wenlin Tai; Nihong Lu; Ting Li; Yongjun Liu; Wenjuan Wu; Zhengkun Li; Lin Pu; Xiaoyuan Zhao; Tao Zhang; Zhaoxing Dong

doi:doi:10.18632/aging.103176

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Research Paper Volume 12, Issue 10 pp 9085—9102

lncRNA ZFAS1 promotes lung fibroblast-to-myofibroblast transition and ferroptosis via functioning as a ceRNA through miR-150-5p/SLC38A1 axis

Figure 7. lncRNA ZFAS1 affects TGF-β1-induced ferroptosis in HFL1 cells by regulating the miR-150-5p/SLC38A1 axis. (A, B) Western blot was performed to detect the level of GPX4 protein; (C) the level of ROS was measured by ROS kit; (D) The MDA content was measured by lipid peroxidation (MDA) assay kit; ^**P<0.01, ^***P<0.001, compared with the control group; ^##P<0.01, ^###P<0.001, compared with the TGF-β1 group; ^▲▲P<0.01, ^▲▲▲P<0.001, compared with the TGF-β1+si-SLC38A1 group.