Research Paper Volume 12, Issue 10 pp 9103—9124

A novel 3’,5’-diprenylated chalcone induces concurrent apoptosis and GSDME-dependent pyroptosis through activating PKCδ/JNK signal in prostate cancer

Figure 8. Schematic diagram depicting the anti-PCa mechanism of C10. C10 stimulated the PKCδ/JNK/IL-6 signaling pathway and thus induced crosstalk between apoptosis and GSDME-dependent pyroptosis in PC3 cells. Red arrows: the new signal transduction pathway discovered in our study, whereby PKCδ/JNK/IL-6 lead to concurrent apoptosis and pyroptosis.