Research Paper Volume 12, Issue 10 pp 9125—9138

Cigarette smoke-induced lung inflammation in COPD mediated via CCR1/JAK/STAT /NF-κB pathway

Figure 8. Cytokine secretion in cellular supernatant. (AC) The CCR1 positive expression may promote the secretion of TNF-α, IL-6, and MIP-1β in cellular supernatant, but these cytokine secretions were also increased in CSE-induced MH-S cells although CCR1 mRNA expression was inhibited. (D) However, the concentration of INF-β in cellular supernatant is not correlated with CCR1 positive expression or CSE stimulation.