Research Paper Volume 12, Issue 9 pp 8652—8668
Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss
Figure 1. Overall workflow of the proteomic profiling of young versus old mouse plasma. (A) Plasma samples were collected from 18 young (2-month-old) and 18 aged (21- to 23-month-old) C57BL/6J mice, and plasma samples from trios of mice were combined to generate six pooled sets per group. (B) Flowchart of the proteomic analysis of mouse plasma and the validation of reverse-aging candidate proteins.