Research Paper Volume 12, Issue 13 pp 12771—12782

HOTAIR expands the population of prostatic cancer stem-like cells and causes Docetaxel resistance via activating STAT3 signaling

Figure 5. HOTAIR promotes tumor growth of xenografted PCa mouse model. (A) HOTAIR Du145 tumors grew faster than control ones. Tumor volume=1/2*short axis2*long axis. (B) IHC staining of Ki67 indicated that HOTAIR Du145 tumors had higher proliferating rate. (C) HOTAIR Du145 mice had poor survival rate compared to control cohorts. (D) IHC staining of p-STAT3. (E) IHC staining of CD133.