Research Paper Volume 12, Issue 10 pp 9205—9223

Identification of potential novel differentially-expressed genes and their role in invasion and migration in renal cell carcinoma

Figure 5. Significantly related genes and hallmarks pathways in ccRCC obtained by GSEA. GSEA was used to perform hallmark analysis for TIMP1 (AC). The most significant pathways included epithelial-mesenchymal-transition, inflammatory-response, and IL6/JAK/STAT3 signaling. (D) Transcriptional expression profiles of the 100 most significant genes expressed as a heat map.