Research Paper Volume 12, Issue 10 pp 9224—9239

Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways

Figure 1. APLN expression is positively correlated with IL-1β expression in OA patients. (A) IHC staining showing increased levels of APLN and IL-1β expression in OA synovial tissue (n=8) compared to normal healthy tissue (n=5). (B, C) The IHC score of APLN and IL-1β are presented. (D) Correlation between levels of APLN and IL-1β expression in synovial tissues retrieved from OA patients.