Research Paper Volume 12, Issue 21 pp 21091—21113

MEX3A is upregulated in esophageal squamous cell carcinoma (ESCC) and promotes development and progression of ESCC through targeting CDK6

Figure 3. MEX3A knockdown inhibited development of ESCC in vivo. Mice xenograft models were constructed through subcutaneously injecting Eca-109 cells with or without MEX3A knockdown. (A) The volume of tumors on mice was measured and calculated at indicated intervals during the culture of the animal models. (B) In vivo imaging of the tumors on mice was facilitated by the injection of D-luciferin before sacrificing the mice. (C) The photos of the tumors removed from the sacrificed mice were collected by a digital camera. (D) Tumor weight was measured after obtaining the removed tumors from animal models. (E) Tumor sections obtained from the removed tumors were subjected to IHC analysis to detect the expression of Ki-67. The data were expressed as mean ± SD (n ≥ 3), *P<0.05, **P<0.01, ***P<0.001.