**Figure 4.** (**A**) Frequency distribution of CNV Gain and Loss. (**B**) Frequency distribution of CNV Gain and MetHyper. (**C**) Frequency distribution of CNV Gain and MetHypo. (**D**) Frequency distribution of CNV Loss and MetHyper. (**E**) Frequency distribution of CNV Loss and MetHypo. (**F**) Frequency distribution of MetHyper and MetHypo.