Research Paper Volume 12, Issue 10 pp 9292—9310

PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma

Figure 6. The expression levels of key piRNAs were corrected by demographic data to construct a multivariate model to distinguish malignant nodules from benign. (A) Nomogram based on multivariate model (A). The calibration curve and ROC curves suggested acceptable calibration (B) and discrimination (C) of the nomogram, respectively. Additionally, piR-13643 (P < 0.001), piR-21238 (P = 0.061) and HBME1 (P = 0.009) were higher in malignant nodules compared to benign nodules in both fresh and paraffin samples (DF).