Figure 8. TLR4 plays a vital role in MPTP-induced pyroptosis. (A) TLR4-Def group inhibited MPTP-induced the reduction of TH-positive neurons in SN and striatum by immunochemical staining (n = 3). Original magnification: x200. (B) Western blotting was performed to determine the expressions of TH and α-syn in SN and striatum of TLR4-Def PD mice (n = 3). All data are represented as mean ± SD. # P < 0.05, ## P < 0.01 vs. control group, *P < 0.05, **P < 0.01 vs MPTP group.