Research Paper Volume 12, Issue 10 pp 9475—9488

Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma

Figure 5. Inhibiting amphiregulin expression suppresses resistance to cisplatin in a nude mouse xenograft model. (A) Body weights are shown for mice treated with cisplatin for 28 days. (B) Tumor growth curves of chondrosarcoma cells treated with cisplatin over 28 days. (C) Representative photomicrographs of cis-SW and cis-SW-shAR cells from nude mice. (D, E) Tumor volumes and weights were measured after the mice were sacrificed. (F) IHC staining detected AR and ABCB1 expression.