Research Paper Volume 12, Issue 10 pp 9489—9499

PI3K-Akt-mTOR inhibition by GNE-477 inhibits renal cell carcinoma cell growth in vitro and in vivo

Figure 4. GNE-477 potently inhibits RCC xenograft tumor growth in mice. The nude mice bearing RCC1 xenograft tumors were intraperitoneally (i.p.) injected with GNE-477 (10-50 mg/kg body weight, daily, for 21 days), AZD2014 (10 mg/kg body weight, daily, for 21 days) or the vehicle control (“Veh”), tumor volumes (A) and mice body weights (D) were recorded every seven (7) days for a total of 35 days; Estimated daily tumor growth, in mm3 per day, was calculated (B); At the last day of recording (Day-35), the xenograft tumors were isolated and weighted (C). For each group, n=10 (mice). ** p < 0.01 vs. “Veh”-treated tumors (AC). * p < 0.05 (AC).