Research Paper Volume 12, Issue 10 pp 9515—9533

Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway

Figure 1. Experimental design of the study and behavior test by Kurlan rating scale. (A) A progressive intoxication protocol of MPTP from 0-22w, MPTP withdraw period from 22-25w, and treatment period from 25-29w. IM: Intramuscular injection; IV: Intravenous injection. (B) Longitudinal evaluation (in weeks) of motor function by Kurlan rating scale for each monkey during the MPTP intoxication and withdraw period.