Research Paper Volume 12, Issue 10 pp 9515—9533

Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway

Figure 7. A summary diagram is shown. In the brain both glial and DA neurons are involved with iron dysfunction during the development of PD. Specifically, both increased levels of ROS and lipid peroxidation (main features of ferroptosis) were happened in the MPTP-induced monkey model, while which could be reversed by low dosage of CQ treatment. So ferroptosis dysfunction probably be involved in the pathogenesis of PD. Meanwhile, the protection effect of CQ was depending on the activation of the AKT/mTOR survival pathway and the prevention of p53-medicated cell death.