Research Paper Volume 12, Issue 10 pp 9549—9584

MiR-1908/EXO1 and MiR-203a/FOS, regulated by scd1, are associated with fracture risk and bone health in postmenopausal diabetic women

Figure 10. miR-203a/FOS and miR-1908/EXO1 are regulated by SCD1. (A) Transfection efficiency of SCD1 in BM-MSCs. (B) Proliferation of BM-MSCs after SCD1 overexpression, miR-1908mimic and miR-203a inhibitor were evaluated. (C) ALP activity was measured in SCD1-overexpressing BM-MSCs treated with miR-203a inhibitor or miR-1908 mimic. (D, E) Expressions of FOS and EXO1 were assessed in BM-MSCs transfected with high-glucose, SCD-OE miR-1908 mimic and miR-203a inhibitor. (F) The regulatory network between dysregulated miRNAs and hub genes after overexpression SCD-1.