Figure 3. Differential expression of miRNA and mRNA. (A) Heat map of Differentially expressed micro-RNAs from GSE70318. (B) Heat map of Differentially expressed mRNAs from GSE25462. Red: upregulation; Blue: downregulation. GSE70318 provides information on serum miRNA signals regarding fractures in postmenopausal women with or without type 2 diabetes. GSE25462 is a dataset of miRNAs related to diabetes and skeletal muscle insulin resistance. We did not find a miRNA dataset directly related to diabetic skeletal disease; considering the close relationship between skeletal muscle and bone (especially fracture risk), and the large size and high quality of the GSE25462 dataset, we used these data.