Research Paper Volume 12, Issue 10 pp 9549—9584

MiR-1908/EXO1 and MiR-203a/FOS, regulated by scd1, are associated with fracture risk and bone health in postmenopausal diabetic women

Figure 7. CDKN1A, FOS, EXO1 and PLS1 are regulated by SCD1. (A) Independent t-test results for the association between mRNAs (EXO1, PLS1, FOS and CDKN1A) and trauma energy in patients with clinical diabetic fractures patients. (B) Human tissue-enriched protein expression map of EXO1, PLS1, CDKN1A and FOS. (C) In the bone marrow, PLS1 and EXO1 are highly expressed, whereas CDKN1A and FOS are relatively low. (D) A represent Western blot showing overexpression of SCD1 in BM-MSCs transduced with lentivirus (“SCD1-OE”). “Control” cells are intact BM-MSCs before transduced with lentivirus. (E) Relative expression of mRNAs (EXO1, PLS1 FOS and CDKN1A) showing overexpression of SCD1 in BM-MSCs transduced with lentivirus (“SCD1-OE”); “Control” cells are intact BM-MSCs before transduced with lentivirus.