Research Paper Volume 12, Issue 10 pp 9585—9603

Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway

Figure 2. Oral administration of cryptotanshinone (CPT) ameliorated cardiac dysfunction in doxorubicin-induced injury. Evaluation of cardiac function by echocardiography with/without CPT treatment, indicated by ejection fraction (EF, %) of LV and fractional shortening (FS, %) of LV, in the doxorubicin-induced rat model (A, B). Measurement of invasive hemodynamic examinations for analyzing both LV pressure and volume (pressure-volume loop) simultaneously, also in the rats model, indicated by end-systolic pressure (Pes), end-diastolic pressure (Ped), maximal rates of the increase in ventricular pressure (dp/dtmax) and maximal rates of decline in ventricular pressure (dp/dtmin) (C). *P<0.05 vs control, #P<0.05 vs DOX.