Figure 4. Cryptotanshinone (CPT) alleviated myocardial mitochondrial membrane potential (MMP) decline and oxidative stress in rats treated with doxorubicin. JC-1 fluorescent mitochondrial depolarization of LV cardiomyocytes for evaluating MMP (A). Detection of intracellular ROS by observing the fluorescence intensity of DCF in the LV of the rats (B). The levels of SOD, MDA, CAT, and GSH-Px in LV tissues of the rats induced by doxorubicin (C). Values are expressed as mean ± standard error of the mean. *P<0.05 vs control, #P<0.05 vs DOX. CAT, Catalase; GSH-Px, glutathinone peroxidase; MDA, malonydialdehyde; SOD, superoxide dismutase. Scale bar: 50 μm.