Research Paper Volume 12, Issue 10 pp 9585—9603

Attenuation of doxorubicin-induced cardiotoxicity by cryptotanshinone detected through association analysis of transcriptomic profiling and KEGG pathway

Figure 7. Cryptotanshinone (CPT) treatment adjusted p53 signaling pathway in the rat heart induced by doxorubicin. Representative blots of 14-3-3σ, p-JNK, JNK, PI3K p85, p-AKT, AKT, and GAPDH (A). Representative blots of Bax, Bak, Bim, PUMA, Bcl-2, Bcl-xl, and GAPDH (B). Representative blots of pro-caspase-3/cleaved caspase-3, pro-caspase-9/cleaved caspase-9, and GAPDH (C). Representative blots of Foxo1, p53, PCNA, and β-tubulin (D). GAPDH, β-tubulin and PCNA were used as internal reference.