Figure 5. KMT2A regulated cervical cancer cell migration and apoptosis through targeting VDAC1. Human cervical cancer Siha and Caski cells were transfected with KMT2A shRNAs or KMT2A shRNA + VDAC1 overexpression plasmid. At 48 hours after transfection, the cell migration and apoptosis rates were measured. (A) The migration ability of Siha and Caski cells was measured by wound-healing assay. (B) The cell migration rate %. (C) Apoptosis of Siha and Caski cells was detected by FACS analysis. (D) Annexin V positive cells %.